31/5/13
New Cases of Neuroimaging & Neuropathology:
F. 48 yr.  Right temporal gliosarcoma.  Original MRI	Same, recurrence 4 months after surgery	First specimen,  glioblastoma component. HE	Same, special stains. Reticulin fibers limited to thickened vessels, absent among tumor cells
Same, immunohistochemistry. Glioblastoma cells positive for GFAP, sarcomatous cells negative	Same, second specimen, after 4 months - gliosarcoma component only. HE	Same, special stains. Collagen fibers surround individual tumor cells	Same, IH
Same, electron microscopy - extracellular matrix with collagen fibrils separate  neoplastic cells		F. 48 yr.  Chordoid meningioma of olfactory groove invading nasal cavity. CT	Same, MRI
Same, HE	Same,  special stains	Same, IH	Same, EM
F. 48 yr.  Single demyelinating lesion of right parieto-occipital region	Same, MRI after 5 months	Same, HE, LFB-Nissl	Same, IH - GFAP, VIM, NF
Same, IH for lymphocytes, macrophages, Ki-67	F. 62 yr.  Amyloid angiopathy and brain hemorrhage	Same, HE, Masson's trichrome. Leptomeningeal vessels with amyloid deposition	Same, Congo red and polarized light. Text

...

26/2/13
New Cases of Neuroimaging & Neuropathology:
M. 27 yr.  Occipital aneurysmal bone cyst	Same, gross specimen, scanned slides. Text.	Same, HE -  membranous septa	Same, HE - new bone deposition at septa
F. 56 yr.  Psammomatous meningioma of olfactory groove	Same, HE		F. 16 yr.  Aneurysmal bone cyst of thoracic spine
F. 17 yr.  Skull base chondroblastoma (temporal bone)	Same, HE - pictured - chondroblasts among chicken wire like calcifications. Text	Same, immunohistochemistry
F. 64 yr.  Glioblastoma multiforme of pineal	Same, HE. Text	Same, IH
F. 52 yr.  B cell lymphoma of dura mater, occipital bone and soft tissues	Same, HE, IH	M. 61 yr. Skull base plasmacytoma (occipital and temporal bones)	Same, HE, IH

20/12/12
New Cases of Neuroimaging & Neuropathology:
F. 20 yr.  Dysembryoplastic neuroepithelial tumor   (DNT) of right superior frontal gyrus. MRI, surgical field pictures, specimen	Same, HE. Text	Same, Masson's trichrome	Same, luxol fast blue - cresyl violet
Same, IH for neurons - MAP2	Same, IH for neurons - NF, tubulin	Same, IH for astrocytes - GFAP, VIM, S-100	Same, IH  - CD34, Ki67
M. 13 yr. DNT of left pre-central gyrus	Same, HE - pictured :  perineuronal satellitosis	M. 24 yr. DNT of left cingulate gyrus at genu of corpus callosum	M. 9 yr. DNT of antero-medial right temporal lobe
F. 8 yr.  DNT of basal gyri of left temporal lobe	F. 7 yr.  DNT of left cuneus	M. 29 yr. DNT of isthmus of right cingulate gyrus. 9-year followup	F. 30 yr.  DNT of antero-medial left temporal lobe
F. 32 yr.  DNT of right middle frontal gyrus	F. 8 yr.  DNT of left middle and inferior temporal gyri
F. 68 yr.  Exophytic meningioma of lesser sphenoid wing with hyperostotic nodule at implantation	Same, specimen, HE	Same, Masson's trichrome	Same, hyperostotic nodule under polarized light
M. 64 yr. Dermoid cyst  (mature teratoma) in cerebellar vermis + posterior fossa arachnoid cyst	Same, specimen, HE

5/12/12
New Cases of Neuroimaging & Neuropathology:
F. 64 yr.  Bifrontal desmoplastic ganglioglioma  above the corpus callosum with areas of central neurocytoma	Same,  ganglioglioma component - gross specimen, smear, paraffin HE	Same, special stains	Same, immunohistochemistry for astrocytes - GFAP, VIM
Case summary
Same, IH for neurons - MAP2, NF	Same, IH for neurons - chromogranin, synaptophysin, class III beta tubulin,  NeuN	Same, IH - CD34, Ki67, p53	Same, electron microscopy - neurons
Same, EM - dendrites, axons, neuropil, synapses	Same, EM - astrocytes, granular bodies, capillary	Same,  central neurocytoma component. HE	Same, IH for astrocytes - GFAP, VIM
Same, IH for neurons -  NF, chromogranin, synaptophysin	Same, IH for neurons - MAP2, NeuN	Same, IH, nestin, CD34, Ki67, p53
M. 30 yr. Hemangiopericytoma of tentorium cerebelli	Same, HE	Same, special stains	Same, IH
Same, EM. Pictured - reticulin fibers

18/9/12
New Cases of Neuroimaging & Neuropathology:
F. 43 yr.  Supratentorial primitive neuroectodermal tumor (PNET).  MRI 2 ½ months after first operation	Same, first sample, HE	Same, second sample, HE	Same, special stains
Same, immunohistochemistry for GFAP, VIM, nestin	Same, IH, tubulin (text), CD56, S-100, NF	Same, IH, CD68, HAM-56,  CD3, CD20	Same, IH, CD34, 1A4, Ki67, p53
Same, electron microscopy		M. 25 yr.  Ganglioglioma exceptionally rich in eosinophilic granular bodies (EGBs)	Same, HE
Same,  special stains	Same, IH - SNF, NF. Pictured - binucleated neuron	Same, IH - GFAP, VIM	Same, IH - CD34, Ki-67. Pictured -'feathery cell'
M. 58 yr. Basilar artery thrombosis in sickle cell disease	Same, pontine infarction	Same, HE  -  coagulation and  liquefaction necrosis, sickled red blood cells in basis pontis	Same, basilar artery thrombus under stereomicroscope and in HE stain
Same, spleen, liver, kidney, lung, HE		M. 62 yr.  Progressive multifocal leucoencephalopathy   (PML)	Same,  HE (needle biopsy). Pictured - atypical astrocytes
		Text (PML)	Text - HIV encephalopathy
M. 25 yr. Progressive multifocal leucoencephalopathy   (PML) affecting cerebellum and brain stem	M. 41 yr. Progressive multifocal leucoencephalopathy   (PML)	M. 47 yr.  HIV encephalopathy	M. 52 yr. HIV encephalopathy

14/8/12
New Cases of Neuroimaging & Neuropathology:
M. 54 yr.  Cerebral histoplasmosis. MRI 9/2011. Hydrocephalus, small periventricular  lesions	Same, MRI 3/2012. Obliteration of third ventricle	Same, CT 3/2012. Small calcified nodule in right anterior horn of lateral ventricle
Case summary,  text.
Same, gross brain pathology. Exudative and hemorrhagic lesions in third ventricle	Same, HE, third ventricle lesions. Histoplasma capsulatum fungi in macrophage phagosomes	Same, HE,  gliotic / fibrotic lesion at anterior commissure  (detected on MRI 6 months previously)	Same, HE, necrotic calcified nodule at right anterior horn of lateral ventricle (also visible on MRI 6 months previously)
Same, HE,  fourth ventricle and leptomeningeal lesions - vasculitis, ependymitis, radiculitis	Same, Masson's trichrome.  Fibrosis of basal leptomeninges	Same, techniques for fungi - Grocott + HE, Grocott + light green, PAS	Same, IH for inflammatory cells : CD68, HAM-56, CD3, CD20
Same, IH for nerve tissue : GFAP, NF (pictured - axons among fungi-filled macrophages)	Same, electron microscopy
M. 44 yr. Oncocytoma (null cell adenoma) of  pituitary	Same, HE	Same, IH. TSH  detectable in few cells, other hormones negative	Same, EM. Tumor cell rich in abnormal mitochondria, rare secretory granules
New slides for  undergraduate Pathology  classes »»»
	A. 271a. Gastric intramucous signet ring adenocarcinoma	A. 98a. Arteriolar hyaline change  of kidney in benign hypertension	A. 98a. Glomerular hyaline change in benign hypertension
A. 72b. Biliary cirrhosis. Bilirubin in dilated intrahepatic bile ducts.	A. 317a. Early  organizing thrombus in femoral vein, recanalized thrombus in artery	A. 317a. Same, Masson's trichrome.	A 193a. Leiomyosarcoma. Nuclear atypia, mitoses

3/6/12
New Cases of Neuroimaging & Neuropathology:
M. 68 yr.  Granular cell astrocytoma of brain. CT, MRIs 2011	Same, MRI, post-operative followup after one year.	Same, HE	Same, special stains : Masson's trichrome, PAS
Case summary,  text.
Same, immunohistochemistry for GFAP	Same, IH, VIM, nestin	Same, CD34	Same, CD68, HAM-56
Same, S-100, NF, CD99	Same, Ki-67, p53	Same, electron microscopy, glutaraldehyde-fixed	Same, EM, from selected paraffin block
M. 59 yr.  Granular cell astrocytoma of brain. HE	Same, IH, GFAP, VIM, S-100	Same, IH, CD34, Ki-67, p53
F. 20 yr. Epidural thoracic ganglioneuroblastoma	Same, HE, text	Same, IH

26/3/12
New Cases of Neuroimaging & Neuropathology:
F. 37 yr.  Intracranial solitary fibrous tumor developing multiple bone metastases 3 years after craniotomy	Same, primary tumor, HE	Same, special stains	Same, IH
Same, vertebral metastasis at T11 with cord compression 3 years later	Same, metastasis, HE, special stains	Same, metastasis, IH
M. 21 yr.  Primary meningeal sarcoma with polyphenotypic antigen expression	Same, HE	Same, special stains	Same, IH, muscle antigens, vimentin
Same, IH, epithelial antigens	Same, IH, neural antigens	Same, IH - CD34, Ki-67, p53
M. 51 yr. Secretory meningioma  at cerebello-pontine angle masquerading as  schwannoma on MRI	Same, HE, special stains	Same, IH
M. 43 yr. Giant bilateral fronto-parietal meningioma  with hyperostosis and brain compression (MRI  Feb 2008)	Same, midline section through infiltrated bone, HE.  Excision of intracranial component deferred due to profuse bleeding	Same, 4 years later.  Tumor growth through bone gap and under scalp (MRI Oct 2011)	Same, intracranial tumor specimen weighed 290 g HE
M. 69 yr. Frontal meningioma  with hyperostosis and bone destruction	Same, HE - intraosseous component. Ischemic necrosis of tumor and bone trabeculae	Same, HE - intracranial component. Cerebral infiltration

17/2/12
New Cases of Neuroimaging & Neuropathology:
F. 58 yr.  Giant cell glioblastoma with a component of conventional glioblastoma multiforme	Same, surgical specimen. Encapsulated tumor with necrotic center	Same, giant cell part  - HE, Masson's trichrome	Same, giant cell part - IH - glial markers, GFAP, VIM, S-100
Same, giant cell part - IH - neuronal markers, SNF, chromogranin, NF, class III beta-tubulin	Same, giant cell part - IH - MAP2, CD34, Ki-67, p53	Same, conventional glioblastoma part  - HE	Same, conventional glioblastoma part - IH - glial markers, GFAP, VIM
Same, conventional glioblastoma part - IH - neuronal markers, NF, MAP2, tubulin. Pictured - neoplastic infiltration among axons	Same, conventional glioblastoma part - IH - CD34, Ki-67, p53		F. 45 yr. Left parietal ganglioglioma
Same, HE. Pictured - multinucleated tumor cell	Same, IH - glial markers, GFAP, VIM	Same, IH - neuronal markers, SNF, NF, chromogranin, NeuN	Same, IH  - MAP2, tubulin, CD34, Ki-67
M. 12 yr. Small solid ganglioglioma of right insula	Same, HE. Pictured - abnormal neuron	Same, IH - glial markers, GFAP, VIM	Same, IH - neuronal markers, SNF, NF, chromogranin, NeuN
Same, IH -  MAP2, tubulin, CD34, Ki-67		F. 51 yr. Solid-cystic ganglioglioma of right temporal and occipital regions	Same, HE, Masson's trichrome. Pictured - multinucleated tumor cell
Same, IH - glial markers, GFAP, VIM	Same, IH - neuronal markers, SNF, chromogranin, NF, NeuN	Same, IH  - MAP2, tubulin, CD34, Ki-67

18/12/11
New Cases of Neuroimaging & Neuropathology:
M. 24 yr.  Atypical central neurocytoma	Same, HE, special stains. Pictured : atypical mitosis. Comment.	Same, IH neuronal markers. Pictured : synaptophysin-positive perivascular pseudorosettes	Same, IH glial markers, CD34, Ki-67 (> 50%)
M. 28 yr. Subependymal giant cell astrocytoma (SEGA) unassociated with tuberous sclerosis	Same, HE - smear, paraffin. Comment. Texts: SEGA, Tuberous sclerosis	Same, IH glial markers	Same, IH neuronal markers
Same, IH nestin, EMA, CD34, Ki-67		M. 26 yr.  Central neurocytoma	Same, HE, IH
M. 35 yr. Central neurocytoma	Same, HE. Text:  Central neurocytoma	Same, IH neuronal markers, CD34	Same, IH glial markers, Ki-67
F. 44 yr.  Ectopic invasive pituitary adenoma centered in sphenoid sinus, spilling into left nasal cavity. Normal sella turcica	Same, specimen, HE. Pictured - nuclear atypia. Text : ectopic pituitary adenoma	Same, special stains. Pictured : mucus filled nasal glands trapped within the adenoma	Same, IH. Pictured : positivity for growth hormone in adenoma cells
F. 54 yr. Cerebro-spinal sarcoidosis	Same, HE, special stains. Text : systemic and CNS sarcoidosis	Same, IH

11/11/11
New Cases of Neuroimaging & Neuropathology:
M. 48 yr.  Primary necrotizing vasculitis of central nervous system	Same, in situ view at surgery, HE	Same, special stains	Text : primary angiitis of brain
M. 16 yr. Left frontal cavernoma, first bleeding. Case summary, CT scans	Same, early phase MRI	Same, control after one year	Same, new bleeding  (2 years from onset)
Same, surgical specimen under stereomicroscope	Same, HE	Same, Masson's trichrome	Text : vascular malformations of the central nervous system: telangiectasias, cavernomas, AVMs.
F. 28 yr. Cavernoma of right cingulate gyrus	Same, surgical specimen under stereomicroscope	Same, HE, Masson's trichrome
F. 46 yr. Bilateral frontal gliomatosis cerebri involving genu of corpus callosum	Same, HE, immunohistochemistry	F. 42 yr. Centroencephalic diffuse large B-cell lymphoma	Same, HE, IH
	Text : gliomatosis cerebri		Text : primary lymphomas of CNS
M. 28 yr. Papillary craniopharyngioma	Same, HE	Same, Masson's trichrome

18/9/11
New Cases of Neuroimaging & Neuropathology:
F. 52 yr.  Anaplastic parietal ganglioglioma	Same, macro specimen, smear, scanned slides	Same, HE	Same, IH : glial markers (GFAP, VIM, S-100); nestin
Same, neuronal markers, CD34, Ki67		M. 55 yr. Frontal ganglioglioma with pilocytic glial component	Same, HE : smear, paraffin
Same, IH : GFAP, VIM	Same, IH : MAP2, chromogranin, NeuN, neurofilament	Same, IH : nestin, CD34, Ki67	Text : gangliogliomas
M. 52 yr.  Sinonasal neuroendocrine carcinoma	Same, specimen, HE	Same, IH : epithelial markers,  vimentin	Same, IH : neural markers
Texts about neuroepithelial tumors of the nasal cavity and paranasal sinuses : olfactory neuroblastoma (1) (2); neuroendocrine carcinoma, sinonasal undifferentiated carcinoma (SNUC).
M. 63 yr. Langerhans cell histiocytosis of orbit	Same, HE	Same, IH	Same, EM
		Texts about : macrophages, dendritic cells, Langerhans cells, Birbeck granules, Langerin, histiocytoses, Langerhans cell histiocytosis, CD1a, CD68.
M. 37 yr. Langerhans cell histiocytosis of spinal canal C7-T1, HE	Same, IH

22/8/11
New Cases of Neuroimaging & Neuropathology:
M. 70 yr.  Atypical meningioma with intra and extracranial growth replacing left side of frontal bone	Same, HE - hipercellularity, small cells, prominent nucleoli	Same, immunohistochemistry. Pictured: EMA positivity in tumor cell membranes.
F. 63 yr. Giant meningioma of olfactory groove	Same, HE : nuclear palisading mimicking schwannoma	F. 57 yr. Meningioma en plaque of middle fossa infiltrating cavernous sinus and middle ear	Same, HE : whorls in middle ear biopsy
M. 60 yr. Metastatic melanoma in genu of corpus callosum mimicking butterfly glioma	Same, HE	Same, IH.  Pictured: HMB-45 positivity in isolated tumor cell	Texts: HMB-45, brain metastases
M. 49 yr. Cerebellar abscess by the fungus Paracoccidioides brasiliensis	Same, HE -  double membrane yeasts, multiple budding	Same, Grocott + hematoxylin	Same, Grocott + light green, PAS + hematoxylin
M. 71 yr. Cerebellar abscess caused by Paracoccidioides brasiliensis	Same, smear : HE, Grocott, Papanicolaou	Same, cell block : HE, Grocott
	Image bank, inflammations, digestive tract »»»
		Helicobacter pylori in gastric biopsy.   Warthin-Starry silver stain

11/6/11
New Cases of Neuroimaging & Neuropathology:
M. 38 yr.  Mucormycosis of nasal cavity, orbit and brain	Same, HE	Same, special stains : Grocott + hematoxylin, Grocott  + HE	Same, Grocott + light green, PAS + hematoxylin
			Text: Mucormycosis
M. 63 yr. Paracoccidioidomycoma of cerebellopontine angle	Same, HE. Pictured : Paracoccidioides brasiliensis in giant cells	Same,  plain Grocott, Grocott  + HE	Same, Grocott + hematoxylin
Same, plain PAS, PAS + hematoxylin		F. 44 yr.  Tanycytic ependymoma of  lumbar spinal cord	Same, HE
M. 42 yr. Primary extracerebral meningeal glioma	Same, HE	Same, HE, Perls	Same, IH
			Text: Primary extracerebral meningeal glioma
Neuro  Image  Bank »»»
	Cerebral chromomycosis (cladosporiosis).  HE	Same, Grocott + hematoxylin	Same, Grocott + light green, Masson's trichrome
			Text: Chromomycosis
Inflammation Image  Bank
Pulmonary cryptococcosis - small subpleural focus. Incidental autopsy finding. HE	Same, special stains : mucicarmine, PAS, Grocott + light green	Pleural and pulmonary mucormycosis. HE	Same, plain Grocott,  Grocott + hematoxylin

15/4/11
New Cases of Neuroimaging & Neuropathology:
F. 9 yr. Supratentorial primitive neuroectodermal tumor (PNET)	Same, specimen, HE	Same, special stains. Pictured : elastic fibers amid tumor cells	Same, immunohistochemistry : GFAP, VIM
Case summary, comment, texts: supratentorial PNETs, elastic fibers, nestin
Same, IH :  nestin, S100, CD56	Same, IH : synaptophysin, chromogranin, NF, EMA	Same, IH : AE1AE3,  1A4,  CD34,  Ki-67,  p53	Same, electron microscopy. Pictured : elastic fibers
F. 71 yr. Extradural spinal leiomyoma	Same, HE, Masson's trichrome, reticulin	Same, IH. Texts: vimentin, intermediate filaments	Same, EM
M. 55 yr. Temporal pilocytic astrocytoma	Same, HE. Pictured : protoplasmatic area with eosinophilic granular bodies (EGBs)	F. 66 yr. Pilocytic astrocytoma of cerebellar vermis in the 7th decade	Same, HE. Pictured : hyalinized vessels
Previously  presented  case  revisited :
		M.  49yr. Ependymoma at foramen of Luschka	Same, HE. Ependymoma featuring hyaline centered rosettes containing elastic fibers
Same, special stains. Pictured : grainy elastic fibers in Verhoeff's stain	Same, IH	Same, EM, general features of ependymoma	Same, EM, clumps of elastic fibers at core of 'hyaline rosettes'