|
|
| Updated 31/5/13 | e-mails : gradanat@fcm.unicamp.br____gradanat@unicamp.br |
| Vascular | Inflammatory | Demyelinating | Tumors (classified) | Tumors (alphabetical) | Malformations | Others |
| Latest additions: 31st May, 2013. Table
of recent additions.
Each clickable thumbnail leads to one case. Please note: all case pages and texts are in Portuguese. Red frame - case also has a Neuropathology page, accessible through bottom of Neuroimaging page. Undergraduate Course in Neuropathology : macro specimens, slides, images & texts (in Portuguese only) Undergraduate Course in Neuroimaging Neuropathology case studies. Correlative Neuropathology - Neuroimaging cases Alphabetical indexes: general; neuropathology & neuroimaging. Profs. Luciano de Souza Queiroz (Dept. of Pathology) and Verônica
de Araújo Zanardi (Dept of Radiology).
|
| VASCULAR
PATHOLOGY ...Neuropathology....
For undergraduates: Neuropathology. Neuroimaging. |
|||
![]() |
![]() |
![]() |
![]() |
| Embolic infarcts | Cavernoma of optic pathways and reactive gliosis mimicking pilocytic astrocytoma | Left temporal cavernoma | Left frontal cavernoma of gyrus rectus |
![]() |
![]() |
![]() |
![]() |
| Cavernoma of spinobulbar transition | F. 28 yr. Large occipital cavernoma (cavernous hemangioma) | M. 38 yr. Left parietal cavernoma (cavernous hemangioma) extending from ventricle to hemispheric surface | F. 28 yr. Cavernoma of right cingulate gyrus |
| Text : vascular malformations of the central nervous system: telangiectasias, cavernomas, AVMs. | |||
![]() |
![]() |
![]() |
![]() |
| M. 16 yr. Left frontal cavernoma, first bleeding. Case summary, CT scans | Same, early phase MRI | Same, control after one year | Same, new
bleeding
(2 years from onset) |
![]() |
![]() |
![]() |
![]() |
| Large right frontal embolized arteriovenous malformation | M. 47 yr. Frontal arteriovenous malformation (AVM) | F. 57 yr. Capillary telangiectases associated with cortical dysplasia | F. 25 yr. Extradural capillary hemangioma of ligamentum flavum compressing thoracic spinal cord |
![]() |
![]() |
![]() |
![]() |
| F. 25 yr. Sickle cell disease. Infarcts of both middle cerebral artery territories. | M. 13 yr. Sickle cell disease. Infarcts of carotid artery territories. Pictured : bilateral absence of carotid flow on MRA. | M. 22 yr. Sickle cell disease. Infarct of left middle cerebral artery territory | F. 19 yr. Sickle cell disease. Multiple infarts, arterial watershed zone lesions |
| Sickle cell disease - illustrated text (Portuguese) | |||
![]() |
![]() |
![]() |
![]() |
| F. 27 yr. Sickle cell disease. Arterial watershed zone lesions in white matter, with cavitations | M. 31 yr. Sickle cell disease. Arterial watershed zone lesions | M. 18 yr. Sickle cell disease. Lacunae in basal ganglia. Arterial watershed zone lesions | M. 58 yr. Basilar artery thrombosis in sickle cell disease |
![]() |
![]() |
![]() |
![]() |
| F. 50 yr. Sturge-Weber syndrome. Calcifications in plain skull X-ray films | M. 12 yr. Sturge-Weber syndrome. Cortical calcifications showing as bands of low signal intensity in T2 WI | M. 1 yr 9 m. Sturge- Weber syndrome. Contrast enhancement of cortical angiomas and choroid plexus in left hemisphere. | M. 48 yr. Primary necrotizing vasculitis of central nervous system. Text |
| Sturge-Weber - Illustrated text (Portuguese) | |||
![]() |
|||
| F. 62 yr. Amyloid angiopathy and brain hemorrhage | |||
|
For undergraduates:...Neuropathology....Neuroimaging. |
| VIRUSES ...Neuropathology. ...For undergraduates:...Neuropathology....Neuroimaging. | |||
![]() |
![]() |
![]() |
![]() |
| M. 44 yr. Progressive multifocal leucoencephalopathy Text | M. 62 yr. Progressive multifocal leucoencephalopathy (PML). Text | M. 25 yr. Progressive multifocal leucoencephalopathy (PML) affecting cerebellum and brain stem | M. 41 yr. Progressive multifocal leucoencephalopathy (PML) |
![]() |
![]() |
![]() |
![]() |
| M. 50 yr. AIDS, giant cell encephalitis | Same, AIDS - Cerebral toxoplasmosis | Same, AIDS, mycobacteriosis of abdominal lymph nodes | M. 47 yr. HIV encephalopathy Text |
![]() |
|||
| M. 52 yr. HIV encephalopathy | |||
| BACTERIA ...Neuropathology. ...For undergraduates:...Neuropathology....Neuroimaging. | |||
![]() |
![]() |
![]() |
![]() |
| M. 12 yr. Cerebral abscess due to Streptococcus intermedius (botryomycosis) | M. 34 yr. Neurotuberculosis in HIV+ patient | ||
| FUNGI ..Neuropathology. ...For undergraduates:...Neuropathology....Neuroimaging. | |||
![]() |
![]() |
![]() |
![]() |
| M. 63 yr. Paracoccidioidomycoma of cerebellopontine angle | M. 49 yr. Cerebellar abscess by the fungus Paracoccidioides brasiliensis | M. 71 yr. Cerebellar abscess caused by Paracoccidioides brasiliensis | M. 38 yr. Mucormycosis of nasal cavity, orbit and brain. Text |
![]() |
![]() |
![]() |
![]() |
| M. 54 yr. Cerebral histoplasmosis. MRI 9/2011. Hydrocephalus, small periventricular lesions | Same, MRI 3/2012. Obliteration of third ventricle | Same, CT 3/2012. Obliteration of third ventricle and small calcified nodule in right anterior horn of lateral ventricle | |
| Case summary, text. | |||
| For cryptococcosis - see Undergraduate course | |||
| PROTOZOA ..Neuropathology. ...For undergraduates:...Neuropathology....Neuroimaging. | |||
![]() |
![]() |
![]() |
![]() |
| F. 32 yr. Neurotoxoplasmosis in HIV+ patient | M. 35 yr. Neurotoxoplasmosis in HIV+ patient | ||
| METAZOA ....Neuropathology. ...For undergraduates:...Neuropathology....Neuroimaging. | |||
![]() |
![]() |
![]() |
![]() |
| M. 49 yr. Spinal racemose cysticercosis (intradural, extramedullary cysts) | M. 35 yr. Giant cysticercus cellulosae of right cerebral hemisphere | F. 67 yr. Necrotic cysticercus cellulosae of cerebral hemisphere - reactional changes in brain tissue | |
![]() |
![]() |
![]() |
![]() |
| M. 32 yr.
Cerebral
schistosomiasis |
F. 37 yr. Spinal cord schistosomiasis | M. 67 yr. Echinococcosis of the central nervous system | |
| OTHERS .....Neuropathology. .. | |||
![]() |
![]() |
![]() |
![]() |
| F. 33 yr. Lymphocytic hypophysitis masquerading as macroadenoma | F. 54 yr. Cerebro-spinal sarcoidosis. Text | ||
| DEMYELINATING DISEASES....Neuropathology. Image bank | |||
![]() |
![]() |
![]() |
![]() |
| F. 32 yr. Pseudotumoral multiple sclerosis. CT, MRI | F. 49 yr. Multiple sclerosis. Acute phase lesions with contrast enhancement | F. 25 yr. Multiple sclerosis. Typical lesions in corpus callosum and corona radiata | F. 39 yr. Multiple sclerosis. Chronic demyelinating lesions in centrum semiovale |
![]() |
![]() |
![]() |
![]() |
| M. 17 yr. Multiple sclerosis. Lesions in corpus callosum and hemispheric white matter | M. 19 yr. Multiple sclerosis. Severe case with widespread multifocal demyelination | F. 50 yr. Multiple sclerosis. Lesions in pons, cerebellum and internal capsule. | F. 13 yr. Severe multiple sclerosis in early adolescence. Two-year follow up |
![]() |
![]() |
![]() |
|
| F. 15 yr. Acute disseminated encephalomyelitis (ADEM), pseudotumoral form | F. 53 yr. Central pontine myelinolysis | M. 49 yr. Central pontine myelinolysis | |
![]() |
![]() |
![]() |
![]() |
| F. 48 yr. Pseudotumoral demyelinating lesion of cerebral hemispheric white matter | F. 49 yr. Pseudotumoral demyelinating lesions in right cerebral hemisphere | F. 48 yr. Single demyelinating lesion at right parieto-occipital region | Same, MRI after 5 months |
|
|
| DIFFUSE
ASTROCYTOMAS - BY TOPOGRAPHY. Neuropathology.
For undergraduates: ....Neuropathology.....Neuroimaging. |
|||
![]() |
![]() |
![]() |
![]() |
| F. 47 yr. Small low grade frontal astrocytoma (incidental MRI finding). | M. 35 yr. Small low grade frontal astrocytoma in premotor area | M. 33 yr. Frontal mesial low grade diffuse astrocytoma | F. 30 yr. Low grade frontal astrocytoma with early anaplasia (foci of contrast enhancement) |
![]() |
![]() |
![]() |
![]() |
| M. 44 yr. Poorly circumscribed low grade frontal astrocytoma | M. 36 yr. Recurrent frontobasal low grade astrocytoma, 6 yr followup | M. 7 yr. Low grade solid-cystic astrocytoma of hemispheric white matter | M. 43 yr. Low grade diffuse astrocytoma of left hemisphere infiltrating from temporal lobe through thalamus |
![]() |
![]() |
![]() |
![]() |
| M. 43 yr. Diffuse temporal astrocytoma, transtentorial herniation and midbrain compression | M. 52 yr. Diffuse temporal astrocytoma infiltrating brainstem | M. 39 yr. Diffuse low grade temporal astrocytoma with anaplastic recurrence after 4 years | M. 32 yr.
Anaplastic solid-cystic
frontal gemistocytic astrocytoma (WHO grade III) |
![]() |
![]() |
![]() |
![]() |
| F. 10 yr. Anaplastic astrocytoma of centrum semiovale | M. 53 yr. Paramedian anaplastic astrocytoma with contralateral extension via corpus callosum | M. 68 yr. Anaplastic astrocytoma of corpus callosum infiltrating from hippocampus to hypothalamus via fornix | F. 54 yr. Low grade astrocytoma of insular region |
![]() |
![]() |
![]() |
![]() |
| M. 34 yr. Low grade astrocytoma of insular region | M. 38 yr. Low grade astrocytoma of insular region | F. 40 yr. Low grade astrocytoma of insular region extending into frontal and temporal lobes | M. 52 yr. Low grade astrocytoma of thalamus with secondary infiltration of hippocampus and insula |
![]() |
![]() |
![]() |
![]() |
| M. 5 yr. Diffuse low grade astrocytoma of thalamus and basal ganglia | F. 51 yr. Low grade astrocytoma of left thalamus extending into centrum semiovale, corpus callosum and right hippocampus | F. 43 yr. Bilateral thalamic astrocytoma | F. 11 yr. Diffuse astrocytoma of right thalamus with anaplastic foci |
![]() |
![]() |
![]() |
![]() |
| M. 37 yr. Anaplastic thalamic astrocytoma | F. 46 yr. Low grade periaqueductal astrocytoma | M. 21 yr. Low grade periaqueductal astrocytoma | M. 8 yr. Anaplastic astrocytoma of pons |
![]() |
![]() |
![]() |
![]() |
| F. 41 yr. Low grade astrocytoma of pons and medulla | M. 36 yr. Diffuse astrocytoma of brain stem | F. 11 yr. Exophytic anaplastic astrocytoma of lateral medulla oblongata | M. 32yr. Low grade astrocytoma of cervical spinal cord |
| GLIOBLASTOMA
MULTIFORME
...Neuropathology.... |
For undergraduates: Neuropathology. Neuroimaging. | ||
![]() |
![]() |
![]() |
![]() |
| Glioblastoma multiforme with unusual presentation and rapid course | Bilateral frontal glioblastoma multiforme | Left frontal giant cell glioblastoma | Glioblastoma multiforme of pontine tegmentum |
![]() |
![]() |
![]() |
![]() |
| Glioblastoma multiforme of cerebellum | Temporoparietal glioblastoma multiforme | F. 59 yr. Left sided temporal glioblastoma multiforme | Same case 9 months after surgery and radiotherapy - pseudotumoral radiation necrosis |
![]() |
![]() |
![]() |
![]() |
| F. 27 yr. Giant cell glioblastoma | F. 5 months. Glioblastoma multiforme of left cerebral hemisphere (presumably congenital) | F. 58 yr. Giant cell glioblastoma with a component of conventional glioblastoma multiforme | F. 64 yr. Glioblastoma multiforme of pineal |
| GLIOSARCOMA ...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| M. 56 yr. Left temporal gliosarcoma. Text | M. 4 d. Congenital gliosarcoma at foramen of Monro, hydrocephalus, spontaneous ventricular bleeding | M. 49 yr. Gliosarcoma of left frontal lobe | F. 48 yr. Right temporal gliosarcoma. Original MRI |
![]() |
|||
| Same, recurrence 4 months after surgery | |||
| GRANULAR CELL ASTROCYTOMA OF BRAIN ...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| M. 68 yr. Granular cell astrocytoma of brain. CT, MRIs 2011. Case summary, text. | Same, MRI, post-operative followup after one year. | ||
| GLIOMATOSIS CEREBRI...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Gliomatosis cerebri secondary to pontine anaplastic astrocytoma | Gliomatosis cerebri secondary to left temporal oligoastrocytoma | F. 6 yr. Gliomatosis cerebri (anaplastic diffuse astrocytoma of rapid growth). 1st MRI | Same, after 40 days. Multiple foci of contrast enhancement |
![]() |
![]() |
![]() |
![]() |
| Gliomatosis
cerebri initiating as left hemispheric
oligoastrocytoma. Early CT, 6/2004 |
Same, focus
of annular enhancement in right hemisphere.
MRI 4/2006 |
Same after
two months: tumor dissemination in right hemisphere.
MRI 6/2006 |
F. 46 yr. Bilateral frontal gliomatosis involving genu of corpus callosum. Text |
| PRIMARY EXTRACEREBRAL MENINGEAL GLIOMA ...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| M. 42 yr. Primary extracerebral meningeal glioma. Text | |||
| PILOCYTIC
ASTROCYTOMA ....Text.......Neuropathology
- cases....
For undergraduates: Neuropathology. Neuroimaging. |
|||
| Cerebellum - classical cases | |||
![]() |
![]() |
![]() |
![]() |
| F. 8 yr. Pilocytic astrocytoma of cerebellum. CT | M. 21 yr. Pilocytic astrocytoma of cerebellum. CT | M. yr. Pilocytic astrocytoma of cerebellum. CT | F. 20 yr. Pilocytic astrocytoma of vermis |
![]() |
![]() |
![]() |
![]() |
| M. 3 yr. Pilocytic astrocytoma of vermis | F. 5 yr. Pilocytic astrocytoma of cerebellar hemisphere | M. 14 yr. Pilocytic astrocytoma of cerebellar hemisphere | F. 23 yr. Pilocytic astrocytoma of cerebellar hemisphere. 17-year follow-up |
| Cerebellum - atypical cases | |||
![]() |
![]() |
![]() |
![]() |
| M. 73 yr. Pilocytic astrocytoma of vermis in the 8th decade. | M. 72 yr. Infiltrating cystic pilocytic astrocytoma of vermis in the 8th decade. | F. 37 yr. Aggressive pilocytic astrocytoma of cerebellum with extensive meningeal infiltration | F. 15 yr. Bilobed, solid and cystic pilocytic astrocytoma of cerebellum with abundant vascular proliferation |
![]() |
![]() |
![]() |
![]() |
| M. 58 yr. Pilocytic astrocytoma of cerebellar vermis with ventricular seeding. 3-year follow-up | M. 63 yr. Cerebellar pilocytic astrocytoma with atypia and high Ki-67 index | ||
![]() |
|||
| F. 66 yr. Pilocytic astrocytoma of cerebellar vermis in the 7th decade | |||
| Midbrain /Quadrigeminal plate | |||
![]() |
![]() |
![]() |
|
| F. 9 yr. Pilocytic astrocytoma of quadrigeminal plate | F. 20 yr. Pilocytic astrocytoma of midbrain | M. 68 yr. Pilocytic astrocytoma of midbrain tegmentum and pons with cerebellar extension | |
| Optic nerve | |||
![]() |
![]() |
||
| F. 9 yr. Pilocytic astrocytoma of optic nerve | M. 11 yr. Pilocytic astrocytoma of optic nerve. Extension to optic chiasm | ||
| Hypothalamus, diencephalon, basal region of cerebral hemispheres | |||
![]() |
![]() |
![]() |
![]() |
| F. 11 yr. Pilocytic astrocytoma of hypothalamic region | M. 21 yr. Pilocytic astrocytoma of optic chiasm and hypothalamic region, anaplastic recurrence | F. 6 yr. Pilocytic astrocytoma of optic chiasm growing into third ventricle | F. 25 yr. Pilocytic astrocytoma of optic chiasm with third ventricle extension |
![]() |
![]() |
![]() |
![]() |
| F. 21 yr. Pilocytic astrocytoma of chiasmatic region and third ventricle | M. 12 yr. Pilocytic astrocytoma of basal cerebral hemisphere | F. 6 yr. Pilocytic astrocytoma of basal cerebral hemisphere recurring after 4 months | F. 49 yr. Pilocytic astrocytoma of deep cerebral hemisphere with explosive growth in 4 months |
| Cerebral hemispheres (cortical-subcortical) | |||
![]() |
![]() |
![]() |
![]() |
| M. 16 yr. Right temporal pilocytic astrocytoma | F. 15 yr. Right temporal pilocytic astrocytoma | F. 15 yr. Pilocytic astrocytoma of isthmus of cingulate gyrus | M. 21 yr. Pilocytic astrocytoma of frontal pole |
![]() |
![]() |
![]() |
![]() |
| M. 46 yr.
Cystic frontal pilocytic astrocytoma
with abundant vascular proliferation |
M. 62 yr. Anaplastic pilocytic astrocytoma of right frontal lobe | M. 24 yr. Occipital pilocytic astrocytoma featuring grossly abnormal vessels, leptomeningeal and parenchymal infiltration and ventricular seeding. Case summary. Text: pilocytic astrocytomas | |
![]() |
|||
| M. 55 yr. Temporal pilocytic astrocytoma | |||
| Intraventricular | Spinal | ||
![]() |
![]() |
![]() |
![]() |
| M. 37 yr.
Intraventricular
pilocytic astrocytoma |
M. 38 yr. Pilocytic astrocytoma of thoracic/lumbar spinal cord | F. 10 yr. Pilocytic astrocytoma of cervical/thoracic spinal cord | M. 28 yr. Pilocytic astrocytoma of brain stem and cervical spinal cord |
| PLEOMORPHIC XANTHOASTROCYTOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Pleomorphic xanthoastrocytoma of left premotor area | Left parieto-occipital pleomorphic xanthoastrocytoma | Left frontal pleomorphic xanthoastrocytoma | Pleomorphic xanthoastrocytoma with lipomatous differentiation |
![]() |
![]() |
![]() |
|
| Complex
glioneuronal tumor:
xanthoastrocytoma- ganglioglioma- ependymoma |
Left parietal pleomorphic xanthoastrocytoma. | F. 14 yr.
Solid-cystic temporal
xanthoastrocytoma |
|
![]() |
![]() |
||
| M. 15 yr. Occipital paraventricular pleomorphic xanthoastrocytoma | Same, recurrence after five years | ||
| TUBEROUS SCLEROSIS & SUBEPENDYMAL GIANT CELL ASTROCYTOMA ...Neuropathology....For undergraduates: Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Subependymal glial nodules | Subependymal glial
nodules, cerebellar calcifications,
sclerosis of diploe |
||
![]() |
![]() |
![]() |
![]() |
| Subependymal giant cell astrocytoma and calcified nodules | Subependymal giant cell astrocytoma | Subependymal giant cell astrocytoma and calcified nodules, cortical tubers | M. 28 yr. Subependymal giant cell astrocytoma (SEGA) unassociated with tuberous sclerosis. Text |
| OLIGODENDROGLIOMA ...Neuropathology....For undergraduates: Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Oligodendroglioma. Calcifications in plain skull radiograph | Oligodendroglioma of left cerebral hemisphere. Calcifications in CT | Oligodendroglioma of left cerebral hemisphere | Operated right frontal oligodendroglioma. Transcalvarian herniation |
![]() |
![]() |
![]() |
![]() |
| Solid-cystic oligodendroglioma of left cerebral hemisphere | Solid-cystic oligodendroglioma of left cerebral hemisphere (another case) | Heavily
calcified
oligodendroglioma, 7-year follow up. CT (2000 - 2006) |
Same, MRI (2006). Diffuse infiltrative growth, invasion of right hemisphere via corpus callosum |
| Case summary | |||
![]() |
![]() |
||
| Same, after 8 months (2007). Development of contrast enhancing anaplastic foci | Oligodendroglioma of basal cerebral hesmisphere | ||
| OLIGOASTROCYTOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Left frontal oligoastrocytoma. | Left temporal oligoastrocytoma with gliomatosis cerebri | Well circumscribed frontal oligoastrocytoma | M. 36 yr.
Anaplastic oligoastrocytoma - radiation brain necrosis after 5 years.
Pictured: original tumor.
Case summary |
| EPENDYMOMA ...Neuropathology....For undergraduates: Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Left hemispheric ependymoma | Left solid-cystic hemispheric ependymoma | Right solid-cystic hemispheric ependymoma | Ependymoma of posterior fossa |
![]() |
![]() |
![]() |
![]() |
| Ependymoma of IVth ventricle | Ependymoma of posterior fossa | Ependymoma of IVth ventricle | Ependymoma of IVth ventricle with cranial and spinal meningeal seeding |
![]() |
![]() |
![]() |
![]() |
| Anaplastic ependymoma of third ventricle | Spinal ependymoma | Ependymoma of IVth ventricle | Anaplastic ependymoma of IVth ventricle, recurrence after 4 years |
![]() |
![]() |
![]() |
![]() |
| Anaplastic ependymoma of pineal region | Anaplastic ependymoma of cerebral hemisphere | Anaplastic ependymoma of cerebral hemisphere (another case) | M. 49 yr. Recurrent ependymoma of foramen of Luschka, with hyaline core rosettes containing elastic fibers |
![]() |
![]() |
![]() |
![]() |
| F. 19 yr. Cellular ependymoma of posterior horn of lateral ventricle | M. 4 yr. Tanycytic ependymoma of third ventricle and foramina of Monro | M. 6 yr. Right sided parieto-occipital tanycytic ependymoma | F. 44 yr. Tanycytic ependymoma of lumbar spinal cord |
| MYXOPAPILLARY EPENDYMOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Myxopapillary ependymoma | Myxopapillary ependymoma (another case) | F. 26 yr. Myxopapillary ependymoma | |
| SUBEPENDYMOMA ...Neuropathology. | EPENDYMOBLASTOMA Neuropathology. | ||
![]() |
![]() |
![]() |
![]() |
| M. 56 yr. Subependymoma of lateral ventricle. Text | F. 49 yr. Subependymoma of lateral ventricle | F. 2 yr 5 m. Frontal ependymoblastoma. Text | |
| CHOROID
PLEXUS PAPILLOMA. ..Neuropathology.
For undergraduates: Neuropathology. |
|||
![]() |
![]() |
![]() |
![]() |
| M. 11 yr. Choroid plexus papilloma of lateral ventricle | F. 9 m. Choroid plexus papilloma of lateral ventricle. Twelve year follow up | M. 30 d. Congenital choroid plexus papilloma of lateral ventricle | F. 32 yr. Choroid plexus papilloma of third ventricle |
![]() |
![]() |
![]() |
|
| M. 26 yr. Calcified choroid plexus papilloma of fourth ventricle | F. 36 yr.
Choroid plexus papilloma of fourth ventricle.
Text on choroid plexus tumors |
M. 52 yr. Choroid plexus papilloma of the lateral recess of the fourth ventricle (at foramen of Luschka) | |
| CHOROID
PLEXUS CARCINOMA. ..Neuropathology.
For undergraduates: Neuropathology. |
|||
![]() |
![]() |
![]() |
![]() |
| F. 1 yr 7 m. Choroid plexus carcinoma of lateral ventricle with seeding through CSF pathways | M. 3 months old. Choroid plexus carcinoma | ||
| ASTROBLASTOMA ..Neuropathology | CHORDOID GLIOMA OF THIRD VENTRICLE Neuropathology | ||
![]() |
![]() |
![]() |
![]() |
| M. 43 yr. Right parietal astroblastoma. Text | F. 43 yr. Chordoid glioma of third ventricle. Text | ||
| GANGLIOCYTOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Gangliocytoma of cerebral gyrus with small ganglioglioma component | |||
| GANGLIOGLIOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Mesial left temporal ganglioglioma | Right temporal ganglioglioma | Right frontal ganglioglioma | Right temporal ganglioglioma associated with cortical dysplasia |
![]() |
![]() |
![]() |
![]() |
| Ganglioglioma of isthmus of right cingulate gyrus | Same, recurring as glioblastoma multiforme after 5 years | Desmoplastic ganglioglioma in an adult, with calcospherites | Classical ganglioglioma of left middle temporal gyrus |
![]() |
![]() |
![]() |
![]() |
| Ganglioglioma associated with dysembryoplastic neuroepithelial tumor (DNT) | Ganglioglioma of left inferior temporal gyrus + cortical dysplasia | Ganglioglioma of spinal cord | Ganglioglioma of left frontal lobe |
![]() |
![]() |
![]() |
![]() |
| Ganglioglioma with sarcomatous component, CT | Same, MRI | F. 29 yr. Solid-cystic right parietal ganglioglioma with features of xanthoastrocytoma | F. 32 yr.
Solid-cystic ganglioglioma
with pilocytic glial component in cerebellum |
![]() |
![]() |
![]() |
![]() |
| M. 22 yr. Ganglioglioma of cerebellum | F. 52 yr. Anaplastic parietal ganglioglioma | M. 55 yr. Frontal ganglioglioma with pilocytic glial component | F. 45 yr. Left parietal ganglioglioma |
![]() |
![]() |
![]() |
![]() |
| M. 12 yr. Small solid ganglioglioma of right insula | F. 51 yr. Solid-cystic ganglioglioma of right temporal and occipital regions | M. 25 yr. Ganglioglioma exceptionally rich in eosinophilic granular bodies (EGBs) | F. 64 yr. Bifrontal desmoplastic ganglioglioma above the corpus callosum with areas of central neurocytoma |
| Case summary | |||
| DESMOPLASTIC
INFANTILE ASTROCYTOMA / GANGLIOGLIOMA
(DIA / DIG)...Neuropathology.... |
|||
![]() |
![]() |
![]() |
![]() |
| M. 1 yr. Desmoplastic infantile astrocytoma Text | M. 2 m. Desmoplastic infantile ganglioglioma Texto | F. 3 m. Desmoplastic infantile ganglioglioma | |
| CENTRAL NEUROCYTOMA.,,.Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Central neurocytoma | Central neurocytoma, another case | Heavily calcified central neurocytoma | F. 18 yr. Central neurocytoma |
![]() |
![]() |
![]() |
![]() |
| M. 24 yr. Atypical central neurocytoma | M. 35 yr. Central neurocytoma. Text | M. 26 yr. Central neurocytoma | F. 64 yr.
Central neurocytoma as component of a desmoplastic bifrontal
ganglioglioma above the corpus callosum |
| Case summary | |||
| DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR (DNT)..Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| M. 23 yr. Dysembryoplastic neuroepithelial tumor (DNT) in right temporal lobe. Text | M. 19 yr. Left frontal DNT | M. 27 yr. Left temporal DNT | F. 26 yr. Right temporal DNT |
![]() |
![]() |
![]() |
![]() |
| M. 14 yr. DNT in left inferior frontal gyrus. | M. 52 yr. Right frontal and temporal mesial DNT | M. 3 yr. DNT in left angular gyrus | F. 4 yr. Ganglioglioma associated with DNT |
![]() |
![]() |
![]() |
![]() |
| M. 43 yr. DNT in left gyrus rectus | F. 20 yr. DNT of right superior frontal gyrus. Text | M. 13 yr. DNT of left pre-central gyrus | M. 24 yr. DNT of left cingulate gyrus at genu of corpus callosum |
![]() |
![]() |
![]() |
![]() |
| M. 9 yr. DNT of antero-medial right temporal lobe | F. 8 yr. DNT of basal gyri of left temporal lobe | F. 7 yr. DNT of left cuneus | M. 29 yr. DNT of isthmus of right cingulate gyrus. 9-year followup |
![]() |
![]() |
![]() |
|
| F. 30 yr. DNT of antero-medial left temporal lobe | F. 32 yr. DNT of right middle frontal gyrus | F. 8 yr. DNT of left middle and inferior temporal gyri | |
| GLIONEURONAL TUMOR...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Glioneuronal tumor with neuropil-like islands and focal transformation to glioblastoma multiforme | |||
| PRIMITIVE NEUROECTODERMAL TUMOR (PNET)...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Left temporal primitive neuroectodermal tumor (PNET) | M. 4 d. Congenital PNET of cerebral hemisphere with ependymal and neuroblastic differentiation. | F. 37 yr. Anaplastic PNET of left frontal lobe | M. 29 yr. Left parietal PNET |
![]() |
![]() |
![]() |
|
| F. 9 yr. Supratentorial (right fronto-temporal) PNET | F. 43 yr. Supratentorial primitive neuroectodermal tumor (PNET). Pre-operative CT | Same, MRI 2½ months after first operation | |
| MEDULLOBLASTOMA.
...Neuropathology....
For undergraduates: Neuropathology. Neuroimaging. |
|||
![]() |
![]() |
![]() |
![]() |
| Desmoplastic medulloblastoma with spinal secondaries | Medulloblastoma of vermis with spontaneous peritumoral hemorrhage. | Large cell medulloblastoma with multiple foci in cerebellum and spinal cord | Recurrent
medulloblastoma with supratentorial
ventricular extension |
| MENINGIOMAS
BY TOPOGRAPHY ...Neuropathology....
For undergraduates: Neuropathology. Neuroimaging. |
|||
![]() |
![]() |
![]() |
![]() |
| Meningiomas of cerebral convexity | Of falx or parafalcine | Of olfactory groove or roof of orbit | Of sellar region |
![]() |
![]() |
![]() |
![]() |
| Of middle fossa | Of sphenoid ridge | Of optic nerve | Of clivus |
![]() |
![]() |
![]() |
![]() |
| Of cerebellopontine angle | Of tentorium /posterior fossa | Intraventricular | Of spinal canal |
| MORE
MENINGIOMAS.
...Neuropathology....
For undergraduates: Neuropathology. Neuroimaging. |
|||
![]() |
![]() |
![]() |
![]() |
| Meningothelial meningioma with rapid growth in young adult | Left intraventricular atypical meningioma | Right frontal meningothelial meningioma infiltrating brain | Three-lobed fibroblastic meningioma (right frontoparietotemporal) |
![]() |
![]() |
![]() |
![]() |
| Left cerebellopontine angle meningioma insinuating into foramen magnum | Left parietal meningioma infiltrating brain | Meningioma of anterior spinal canal (T2-T3) | Meningioma of olfactory groove |
![]() |
![]() |
![]() |
![]() |
| Right frontobasal meningioma (incidental finding) + aneurysm of right middle cerebral artery | Chordoid meningioma of right fronto-temporal region | Lymphoplasmacyte-rich meningioma en plaque of orbital roof growing into basal cisterns. 10-year follow-up | Secretory meningioma of planum sphenoidale |
![]() |
![]() |
![]() |
![]() |
| Microcystic meningioma of falx | Atypical meningioma. 10-year follow-up | Meningioma originating in middle ear | Same, intracranial extension after 4 years. |
![]() |
![]() |
![]() |
![]() |
| Secretory meningioma of sphenoid wing with hyperostosis. CT, MRI | F. 13 yr. Clear cell meningioma of posterior fossa | M. 51 yr. Lipidized meningioma (with adipose tissue metaplasia) of sphenoid wing | F. 52 yr. Lipidized meningioma of petrous apex |
![]() |
![]() |
![]() |
![]() |
| F. 57 yr. Temporal lipidized meningioma | F. 42 yr. Recurrent chordoid meningioma invading frontal sinus | M. 49 yr. Xanthomatous and angiomatous meningioma of left parietal convexity | F. 66 yr. Parafalcine meningioma with microcystic, xanthomatous, angiomatous and meningothelial components |
![]() |
![]() |
![]() |
![]() |
| F. 29 yr. Complex meningioma combining rhabdoid, papillary and clear cell patterns | F. 75 yr.
Fibroblastic meningioma of left lateral ventricle |
M. 70 yr. Atypical meningioma with intra and extracranial growth replacing left side of frontal bone | F. 63 yr. Giant meningioma of olfactory groove |
![]() |
![]() |
![]() |
![]() |
| F. 57 yr. Meningioma en plaque of middle fossa infiltrating cavernous sinus and middle ear | M. 51 yr. Secretory meningioma at cerebello-pontine angle masquerading as schwannoma on MRI | M. 43 yr.
Giant bilateral
fronto-parietal meningioma with hyperostosis and brain compression (MRI Feb 2008) |
Same, 4
years later.
Tumor growth through bone gap and under scalp (MRI Oct 2011) |
![]() |
![]() |
![]() |
![]() |
| M. 69 yr. Frontal meningioma producing hyperostosis and bone destruction | F. 68 yr. Exophytic meningioma of lesser sphenoid wing with hyperostotic nodule at implantation | F. 56 yr. Psammomatous meningioma of olfactory groove | F. 48 yr. Chordoid meningioma of olfactory groove invading nasal cavity. CT |
![]() |
|||
| Same, MRI | |||
| HEMANGIOPERICYTOMA ...Neuropathology.__Text | |||
![]() |
![]() |
![]() |
![]() |
| M. 33 yr. Hemangiopericytoma with falx attachment | M. 30 yr. Hemangiopericytoma of tentorium cerebelli | ||
| SOLITARY FIBROUS TUMOR OF THE MENINGES.....Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Solitary fibrous tumor of falx. Text | Solitary fibrous tumor of meninges | Solitary fibrous tumor of meninges | |
![]() |
![]() |
||
| F. 37 yr. Intracranial solitary fibrous tumor developing multiple bone metastases 3 years after craniotomy | Same, vertebral metastasis at T11 with cord compression 3 years later | ||
| SCHWANNOMA
...Neuropathology....
For undergraduates: Neuropathology. Neuroimaging. |
|||
![]() |
![]() |
![]() |
![]() |
| Diminutive intracanalicular acoustic schwannoma | Acoustic schwannoma | Acoustic schwannoma | Acoustic schwannoma |
![]() |
![]() |
![]() |
![]() |
| Acoustic schwannoma | Acoustic schwannoma | Solid-cystic acoustic schwannoma | Schwannoma of cauda equina |
![]() |
![]() |
![]() |
![]() |
| Schwannoma of cervical nerve root (right C4) | Schwannoma of cervical nerve root (right C7) | Giant schwannoma of sacral nerve root (right S1) | Schwannoma of cauda equina at conus medullaris |
![]() |
![]() |
![]() |
|
| Recurrent vestibular schwannoma compressing brain stem | M. 27 yr. Schwannoma of trigeminal nerve root or of Gasserian ganglion | M. 28 yr. Multiple schwannomas of cauda equina | |
| NEUROFIBROMATOSIS TYPE 1 (NF1) | |||
![]() |
![]() |
![]() |
![]() |
| M. 23 yr. NF1. Diffuse astrocytoma of cerebellum, sphenoid dysplasia, high signal intensity focus in globus pallidus | M. 10 yr. NF1. Diffuse astrocytoma of optic pathways, gliomatosis of brain stem and cerebral hemispheres | ||
![]() |
![]() |
![]() |
![]() |
| F. 6 yr. NF1. Diffuse astrocytoma of optic pathways, gliomatosis of brain stem and centroencephalic structures, neurofibroma of scalp | F. 9 yr. NF1. Pilocytic astrocytoma of optic nerve | ||
![]() |
![]() |
![]() |
![]() |
| F. 12 yr. NF1. Sphenoid dysplasia, neurofibromas of orbit and scalp, enlarged cisterna magna, foci of abnormal signal intensity in cerebellar vermis and globus pallidus | M. 14 yr. NF1. Multiple foci of abnormal signal intensity ('hamartomas') in brain. | ||
![]() |
![]() |
![]() |
![]() |
| F. 25 yr. NF1. Foci of abnormal signal intensity ('hamartomas') in brain. | M. 11 yr. NF1. Sphenoid dysplasia, neurofibroma of orbit, proptosis, bilateral foci of abnormal signal intensity in globus pallidus | ||
![]() |
![]() |
![]() |
![]() |
| M. 30 yr. NF1. Plexiform neurofibroma, sphenoid dysplasia, middle fossa arachnoid cyst, craniofacial deformity | F. 24 yr. NF1. Plexiform neurofibroma of face and scalp, sphenoid dysplasia, middle fossa arachnoid cyst, craniofacial deformity, proptosis and buphthalmos. | ||
![]() |
![]() |
![]() |
![]() |
| M. 13 yr. NF1. Plexiform neurofibroma of scalp and ear, posterior fossa arachnoid cyst | M. 17 yr. NF1. Plexiform neurofibroma of nuchal region with malignant transformation (malignant peripheral nerve sheath tumor, MPNST). | ||
![]() |
![]() |
![]() |
![]() |
| M. 56 yr. NF1. Multiple tumors of spinal nerve roots | F. 11 yr. NF1. Multiple tumors of spinal roots and nerves extending widely into paravertebral muscles | ||
![]() |
![]() |
![]() |
![]() |
| M. 66 yr. NF1. Lateral meningoceles of thoracic and sacral regions, marked kyphoscoliosis, cutaneous neurofibromas. | |||
| NEUROFIBROMATOSIS TYPE 2 (NF2) | |||
![]() |
![]() |
![]() |
![]() |
| M. 11 yr. NF2. Bilateral vestibular schwannomas, ependymoma of medulla and cervical cord, meningiomas of foramen of Luschka and lateral ventricle. | M. 25 yr. NF2. Bilateral vestibular schwannomas, ependymoma of cervical cord, cavernous sinus meningioma (arrow), optic nerve sheath tumor (also meningioma?) | ||
![]() |
![]() |
![]() |
|
| F. 51 yr. NF2. Multiple meningiomas (meningiomatosis), left vestibular schwannoma , ependymoma of spinobulbar transition. | |||
![]() |
![]() |
Illustrated
linked texts (in Portuguese): schwannomas,
neurofibromas,
NF1, NF2. |
|
| M. 42 yr. NF2. Left vestibular schwannoma, meningioma of petrous apex and sphenoid, tentorial meningioma surrounding straight sinus | |||
| GANGLIONEUROBLASTOMA...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| F. 20 yr. Epidural thoracic ganglioneuroblastoma. Text. | |||
| NEUROBLASTOMA...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| M. 40 yr. Olfactory neuroblastoma (esthesioneuroblastoma) | F. 28 yr. Neuroblastoma of olfactory nerve (esthesioneuroblastoma) | M. 36 yr. Esthesioneuroblastoma with frontal lobe extension | M. 46 yr.
Esthesioneuroblastoma causing frontal lobe hemorrhage |
![]() |
|||
| M. 11 m. Retroperitonial neuroblastoma metastatic to skull | |||
| NEUROENDOCRINE CARCINOMA ...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| M. 52 yr. Sinonasal neuroendocrine carcinoma | |||
| HEMANGIOBLASTOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Hemangioblastoma of cervical cord with hydrosyringomyelia | Hemangioblastoma of spinobulbar transition | Cerebellar hemangioblastoma | Cerebellar hemangioblastoma |
![]() |
![]() |
![]() |
|
| Left hemispheric solid cerebellar hemangioblastoma | Midline solid-cystic cerebellar hemangioblastoma | Hemangioblastoma of cervical cord | |
| LYMPHOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Lymphoma of basal ganglia | Lymphoma of cerebral hemisphere | Primary B-cell non-Hodgkin lymphoma of occipital bone. Text | Recurrent Hodgkin's lymphoma in thoracic vertebrae and soft tissues, causing root compression. |
![]() |
![]() |
![]() |
![]() |
| B-cell lymphoma of cerebellum and pituitary | M. 25 yr.
Systemic T/NK cell lymphoma masquerading as multiple sclerosis
Case summary |
F. 27 yr. Diffusely infiltrating, non contrast enhancing B-cell lymphoma | F. 60 yr. Primary dural lymphoma with extracranial extension. 12-year follow-up |
![]() |
![]() |
![]() |
|
| F. 56 yr. Marginal zone non Hodgkin B-cell lymphoma of skull base at left cavernous sinus | F. 42 yr. Centroencephalic diffuse large B-cell lymphoma. Text | F. 52 yr. B cell lymphoma of dura mater, occipital bone and soft tissues | |
| MULTIPLE MYELOMA / PLASMACYTOMA...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| M. 59 yr. Multiple myeloma of spine | F. 45 yr. Plasmacytoma of skull base | M. 61 yr. Skull base plasmacytoma (occipital and temporal bones) | |
| HISTIOCYTOSES. ..Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Non Langerhans histiocytosis of skull base and sellar region. Early lesions CT, MRI | Same, follow up MRI after 4 months | Non Langerhans histiocytosis of meninges and brain. Early lesions, MRI | Same, follow up MRI after 6 months |
![]() |
![]() |
||
| Langerhans histiocytosis (eosinophil granuloma) of skull and sternum | M. 63 yr. Langerhans cell histiocytosis of orbit | ||
| METASTASES. ...Neuropathology....For undergraduates: Neuropathology. Neuroimaging. | |||
![]() |
![]() |
![]() |
![]() |
| Metastatic neuroendocrine carcinoma | Pontine metastasis of renal carcinoma | Metastatic breast carcinoma in posterior fossa mimicking meningioma | Left frontal metastatic melanoma |
![]() |
![]() |
![]() |
![]() |
| Right temporal metastatic colon carcinoma | Metastatic adenoid cystic carcinoma in spine and thoracic wall | Cerebellar metastasis of neuroendocrine carcinoma | F. 75 yr. Occipital metastasis of follicular carcinoma of thyroid. 4-year history |
![]() |
![]() |
![]() |
![]() |
| M. 11 m. Retroperitonial neuroblastoma metastatic to skull | M. 60 yr. Widespread cerebral metastases of lung adenocarcinoma | F. 15 yr. Three metastases of choriocarcinoma (primary in hydatiform mole) | M. 22 yr. Two metastases of choriocarcinoma (primary in mediastinum) |
![]() |
![]() |
![]() |
![]() |
| F. 68 yr. Skull metastasis of follicular adenocarcinoma of thyroid | M. 59 yr. Metastatic neuroendocrine carcinoma in cerebral hemisphere | F. 75 yr. Metastatic adenocarcinoma in sphenoid wing mimicking meningioma on MRI | M. 60 yr. Metastatic melanoma in genu of corpus callosum mimicking butterfly glioma |
| CRANIOPHARYNGIOMA...Neuropathology....For undergraduates: Endocrine Pathology | |||
![]() |
![]() |
![]() |
![]() |
| Calcified craniopharyngioma in plain skull radiographs | Peripherally calcified craniopharyngioma causing enlargement of sella | Craniopharyngioma: large, solid-cystic, partly calcified tumor | Craniopharyngioma: tumor growth over one year |
![]() |
![]() |
![]() |
![]() |
| Craniopharyngioma: five-year follow-up | Craniopharyngioma: 12-year follow-up | Bilobed craniopharyngioma involving the optic chiasm | Solid-cystic craniopharyngioma |
![]() |
![]() |
![]() |
![]() |
| Craniopharyngioma: complete ressection | Papillary craniopharyngioma | Papillary craniopharyngioma: frontal lobe extension | Intrasellar craniopharyngioma |
![]() |
![]() |
![]() |
![]() |
| Papillary craniopharyngioma | M. 44 yr. Adamantinomatous craniopharyngioma extending into third ventricle | M. 54 yr. Adamantinomatous craniopharyngioma. Large cyst filling prepontine cistern and third ventricle | M. 44 yr. Adamantinomatous craniopharyngioma extending into frontal lobes |
![]() |
![]() |
||
| M. 31 yr. Presumed craniopharyngioma with fluid level (specimen contained only pilocytic gliosis, but no tumor) | M. 28 yr. Papillary craniopharyngioma | ||
| EPIDERMOID / DERMOID CYSTS ...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Epidermoid cyst of posterior fossa | Epidermoid cyst of right choroid fissure | M. 33 yr. Epidermoid cyst of right choroid fissure and arachnoid cyst of posterior fossa. Text | M. 25 yr.
Dermoid cyst (mature cystic teratoma) of sellar region. Spread of lipid droplets through subarachnoid space and lateral ventricle. Text |
![]() |
|||
| M. 64 yr. Dermoid cyst (mature teratoma) in cerebellar vermis and posterior fossa arachnoid cyst | |||
| PITUITARY ADENOMAS. ..Neuropathology...For undergraduates: Endocrine Pathology | |||
![]() |
![]() |
![]() |
![]() |
| Microadenoma (prolactinoma) | Microadenoma (prolactinoma) | Microadenoma (prolactinoma) | Macroadenoma |
![]() |
![]() |
![]() |
![]() |
| Macroadenoma (prolactinoma) | Partly cystic macroadenoma | Cystic macroadenoma showing sedimentation level | Cystic macroadenoma: two-year follow-up |
![]() |
![]() |
![]() |
![]() |
| Macroadenoma - regression in response to clinical treatment | GH-secreting macroadenoma causing acromegaly | Pituitary oncocytoma (null cell adenoma, oncocytic variant) | M. 49 yr. Giant invasive pituitary adenoma infiltrating skull base and nasopharynx |
![]() |
![]() |
||
| F. 44 yr. Ectopic invasive pituitary adenoma centered in sphenoid sinus, spilling into left nasal cavity. Normal sella turcica. Text | M. 44 yr. Oncocytoma (null cell adenoma) of pituitary | ||
| TUMORS OF THE PINEAL REGION | |||
| GERMINAL TUMORS ...Neuropathology. Texts (1) (2) | |||
![]() |
![]() |
![]() |
![]() |
| M. 19 yr. Germinoma of pineal | M. 29 yr. Germinoma of pineal | M. 21 yr. Germinoma of pineal | M. 19 yr. Germinoma of pineal |
![]() |
![]() |
![]() |
![]() |
| M. 9 yr. Germinoma of pineal | M. 28 yr. Germinoma of pineal | F. 12 yr. Germinoma of hypothalamic region | M. 21 yr. Germinoma of hypothalamic region infiltrating dorsum sellae, cavernous sinuses and compressing optic chiasm |
![]() |
![]() |
||
| M. 9 yr. Germinoma of pineal. Seeding of cranial subarachnoid space and lumbar nerve roots. Two-year follow-up. | F. 16 yr. Germinoma of hypothalamic region disseminating to IV ventricle | ||
![]() |
![]() |
![]() |
![]() |
| M. 5 yr. Teratoma (dermoid cyst) of pineal - CT | Same, MRI | M. 13 yr. Teratoma of pineal. Free lipid droplets in lateral ventricles | |
| PINEAL PARENCHYMAL TUMORS, OTHERS...Neuropathology. .Text | |||
![]() |
![]() |
![]() |
![]() |
| F. 24 yr. Pineocytoma. Text | F. 56 yr. Pineocytoma | F. 20 yr. Pineoblastoma. Text | M. 15 yr. Pineoblastoma |
![]() |
![]() |
![]() |
![]() |
| F. 14 yr. Pineoblastoma | F. 64 yr. Glioblastoma multiforme of pineal. Text | M. 9 yr. Pineal cyst. Text | F. 58 yr. Three-lobed cyst of pineal |
| CHORDOMA ...Neuropathology....Text | |||
![]() |
![]() |
![]() |
![]() |
| Chordoma of clivus | Chordoma of clivus | Chordoma of clivus | Chordoma of 5th lumbar vertebra extending into spinal canal |
![]() |
![]() |
![]() |
|
| Sacrococcygeal chordoma | Sacrococcygeal chordoma | Sacral chordoma with massive recurrence after 6 years | |
| PARAGANGLIOMAS ...Neuropathology....Text | |||
![]() |
![]() |
![]() |
![]() |
| Carotid body paraganglioma | F. 52 yr. Gangliocytic paraganglioma of cauda equina | F. 54 yr. Paraganglioma of cauda equina | |
| BONE TUMORS. ..Neuropathology....For undergraduates... | |||
![]() |
![]() |
![]() |
![]() |
| M. 23 yr. Giant cell tumor of sacrum and lumbar vertebrae. Text | F. 16 yr. Aneurysmal bone cyst of sacrum. Text | M. 27 yr. Occipital aneurysmal bone cyst. Text | F. 16 yr. Aneurysmal bone cyst of thoracic spine |
![]() |
![]() |
![]() |
|
| F. 31 yr. Osteosarcoma of clivus secondary to irradiation for craniopharyngioma | M. 42 yr. Chondroma of skull base at petrous apex / cavernous sinus. Text | F. 17 yr. Skull base chondroblastoma (temporal bone). Text | |
| LEIOMYOMA...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| F. 71 yr. Extradural spinal leiomyoma | |||
| MELANOCYTOMA...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Melanocytoma of sellar region. Six-year follow-up | |||
| PERIPHERAL
PRIMITIVE NEUROECTODERMAL TUMOR (pPNET)
......Neuropathology. |
|||
![]() |
![]() |
![]() |
![]() |
| F. 21 yr. Peripheral primitive neuroectodermal tumor (pPNET) of cervical nerve root. Text | F. 37 yr. Ewing's sarcoma / peripheral primitive neuroectodermal tumor (pPNET) of lumbar nerve roots invading vertebrae | M. 21 yr. Peripheral primitive neuroectodermal tumor (pPNET) of lumbar nerve roots with paravertebral soft tissue extension | M. 26 yr. Peripheral primitive neuroectodermal tumor (pPNET) of cauda equina |
![]() |
|||
| F. 15 yr. pPNET (peripheral primitive neuroectodermal tumor) / Ewing's sarcoma of spinal epidural space (T11-T12) compressing cord and nerve root . | |||
| SARCOMA.....Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| M. 17 yr. Primary myxoid sarcoma of brain. Early lesion in left parietal lobe | Same, rapid tumor growth in 2½ months | Same, first recurrence at left temporal lobe after 6 months | Same, second recurrence after 3 years, elsewhere in left parietal lobe |
| Case summary | |||
![]() |
![]() |
||
| Same, third recurrence after 4 years at left frontal lobe | M. 21 yr. Primary meningeal sarcoma with polyphenotypic antigen expression | ||
| MALFORMATIONS, MIGRATION DEFECTS ...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Pachygyria | Double cortex | Double cortex | Heterotopia |
![]() |
![]() |
![]() |
![]() |
| Heterotopia | Heterotopia | Schizencephaly, polymicrogyria, agenesis of septum pellucidum | Schizencephaly, polymicrogyria, agenesis of septum pellucidum |
![]() |
![]() |
![]() |
![]() |
| Cortical dysplasia, Taylor type | Cortical dysplasia, Taylor type | Cortical dysplasia, Taylor type | Non-Taylor cortical dysplasia (normal MR) |
![]() |
![]() |
![]() |
![]() |
| M. 15 yr.
Non-Taylor cortical dysplasia + incidental pleomorphic
xanthoastrocytoma |
Polymicrogyria and cystic leukomalacia | F. 40 yr. Frontoethmoidal (frontonasal) cephalocele | F. 5 yr.
Frontoethmoidal (fronto-orbital) cephalocele |
| CYSTS, HAMARTOMAS, OTHERS...Neuropathology. | |||
![]() |
![]() |
![]() |
![]() |
| Congenital arachnoid cyst | Arachnoid cyst of posterior fossa (+ epidermoid cyst of choroidal fissure) | F. 27 yr. Intradiploic arachnoid cyst. Text | M. 64 yr. Dermoid cyst (mature teratoma) in cerebellar vermis and posterior fossa arachnoid cyst |
![]() |
![]() |
![]() |
![]() |
| M. 45 yr. Cervical epidural meningeal cyst. Text | F. 15 yr. Multiple epidural meningeal cysts | F. 45 yr. Spinal enterogenous cyst | M. 24 yr. Spinal enterogenous cyst |
![]() |
![]() |
![]() |
![]() |
| M. 43 yr.
Colloid cyst of third ventricle. CT.
Image bank |
F. 62 yr. Colloid cyst of third ventricle. CT | M. 14 yr. Colloid cyst of third ventricle. CT, MRI | M. 36 yr. Colloid cyst of third ventricle causing unilateral hydrocephalus. CT, MRI |
![]() |
![]() |
![]() |
![]() |
| M. 40 yr. Colloid cyst of third ventricle. CT, MRI | M. 61 yr. Colloid cyst of third ventricle causing bilateral hydrocephalus. CT, MRI | F. 37 yr.
Rathke's cleft cyst. CT, MRI
Image bank |
F. 46 yr. Rathke's cleft cyst. MRI |
![]() |
![]() |
![]() |
![]() |
| F. 42 yr. Rathke's cleft cyst. MRI | M. 25 yr. Hypothalamic hamartoma. Text | F. 3 yr. Hypothalamic hamartoma | F. 3 yr. Hypothalamic hamartoma |
![]() |
|||
| F. 1 yr. 7m. Hypothalamic hamartoma | |||
| OTHER DISEASES...Neuropathology.... | |||
![]() |
![]() |
![]() |
![]() |
| Late pseudotumoral necrosis after gamma knife irradiation for cavernoma | Radiation induced demyelinating white matter lesions 4 years after oligoastrocytoma | Same case,
late pseudotumoral brain necrosis after 5 years
Case summary |
Pseudotumoral brain necrosis 9 months after radiation therapy for glioblastoma multiforme |