Research activities: the Human Cytogenetics Laboratory began operating shortly after the creation of the Department of Medical Genetics by Professor Dr. Bernardo Beiguelman, which took place with the founding of the Faculty of Medical Sciences in 1963. Initially, the cytogenetic unit was installed on the ground floor of the building of the Maternity Hospital of Campinas, for conducting practical classes for the medicine course, the same place where the professor Beiguelman began to study the behavior of macrophages in leprosy. Already at that time, overcoming several structural problems, the first research results were internationally recognized. In 1966, Beiguelman becomes a consultant of the World Health Organization and begins his participation in international conferences. The laboratory, following the Department of Medical Genetics, was transferred, in 1968, to the newly created campus "University City Zeferino Vaz", where it was allocated in the Biology Institute. In mid-1969, with the founding of the first Clinical Genetics Service of Brazil, this laboratory becomes extremely important to support researches performed in this clinic, when human karyotype analysis began to be regularly performed. In 1987, it was transferred to the Clinical Hospital and, in 1997, to the main building of the Faculty of Medical Sciences complex, where it is currently located. Over the past 10 years, under the responsibility of Professor Dr. Vera Lucia Gil da Silva Lopes, the Human Cytogenetic Laboratory has undergone renovations to the adequacy of its infrastructure for research activities and was fully re-equipped for the performance of new techniques of molecular cytogenetics. Currently researches are carried out in different areas, such as clinical cytogenetics, craniofacial genetics and disorders of sexual differentiation, mainly using the FISH (fluorescence in situ hybridization) technique and array genomic hybridizations.
Sigla do Laboratório:
Társis Antonio Paiva Vieira; Vera Lúcia Gil da Silva Lopes
Linhas de pesquisa:
clinical cytogenetics; craniofacial genetics; disorders of sexual differentiation; genomic imbalances.
clinical cytogenetics; craniofacial anomalies; disorders of sexual differentiation; 22q11.2 microdeletion; genomic hybridization arrays; next-generation sequencing
Principais equipamentos utilizados para o desenvolvimento das pesquisas:
Cabines de segurança biológica (fluxo laminar); incubadoras de CO2; microscópios ópticos comuns e de fluorescência; sistemas de análise de imagens; freezer -80ºC; shaker, microcentrífuga refrigerada; termocilcador. Além destes, o laboratório conta com o apoio de equipamentos multiusuários instalados no Laboratório de Genética Molecular e no LaCTAD , para realização das pesquisas.
Fundos de financiamento:
Outras agências ou convênios que financiam os projetos do laboratório:
Nilma Lúcia Viguetti Campos; Ilária Cristina Sgardioli; Ana Paula dos Santos
Jair Bueno de Oliveira
FCM01 - Faculdade de Ciências Médicas
Rua Tessália Vieira de Camargo
Cidade Universitária Zeferino Vaz